Impaired approach to novelty and striatal alterations in the oxytocin receptor deficient mouse model of autism. Modi ME(1), Inoue K(2), Barrett CE(2), Kittelberger KA(2), Smith DG(3), Landgraf R(4), Young LJ(2). Epub 2006 Jan 25. This site needs JavaScript to work properly. Here we test whether OTRs in the NAc modulate a social salience network (SSN)-a network of interconnected brain nuclei thought to encode valence and incentive salience of sociosensory cues-during a social context in the socially monogamous male prairie vole. Horm Behav. Johnson ZV, Walum H, Jamal YA, Xiao Y, Keebaugh AC, Inoue K, Young LJ. Read more about our.  |  Neurosci Biobehav Rev. Central OTRs exhibit extraordinarily diverse expression patterns that are associated with individual and species differences in social behavior. Effects of Stroking on Salivary Oxytocin and Cortisol in Guide Dogs: Preliminary Results. Oxytocin receptor density in the nucleus accumbens is highly variable in virgin female prairie voles, as is their behavioral response to pups, ranging from neglecting and infanticidal to full maternal behavior. Hayashi R, Kasahara Y, Hidema S, Fukumitsu S, Nakagawa K, Nishimori K. Front Endocrinol (Lausanne). Epub 2019 Aug 24. The CRISPR/Cas9 system has great potential for efficiently generating mutants in non-traditional animal models and consequently to reinvigorate comparative behavioral neuroendocrinology. Sex-Specific Differences in Oxytocin Receptor Expression and Function for Parental Behavior. Neuropharmacology. Prairie vole pups exposed to the antidepressant fluoxetine in the womb show autism-like behaviors and lose some brain receptors for oxytocin and the related hormone vasopressin. A comparison of … No differences were found in other brain regions (medial preoptic area, septum, prelimbic cortex). Oxtr Δ60/Δ60 prairie voles showed a complete absence of OXTR binding in brain. Epub 2020 Jun 18. The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. Females that showed maternal behavior (lick and groom the pups and hover over them for at least 30 s, n=24) had higher oxytocin receptor density in the nucleus accumbens (shell subregion) (P<0.05) than females that did not show maternal behavior or attacked the pups (n=16). Oxtr mutant male voles show no disruption in pup ultrasonic vocalization, anxiety as measured by the open field test, alloparental behavior, or sociability in the three chamber test. At the new Center for Translational Social Neuroscience at Emory University, created last month and launched publicly at the meeting, Young plans to study the role of oxytocin and other compounds in regulating social behavior of voles and non-human primates. Genome editing will enhance the utility of prairie voles for studying mechanisms of behavior. Larry Young, a pioneer in the field, may have solved this problem. Young LJ, Winslow JT, Wang Z, Gingrich B, Guo Q, Matzuk MM, Insel TR. This is the first study to show that the nucleus accumbens is involved in the regulation of "spontaneous" maternal behavior and that oxytocin receptor in this brain region facilitates maternal responses. Animals (Basel). Gend Genome. The prairie vole is special for having pair bonding with its partner. Horm Behav. Animals infused with CSF or oxytocin receptor antagonist into the caudate putamen did not differ (four/10, four/10). Social behavior is regulated by conserved neural networks across vertebrates. Yee has found that pretreatment with oxytocin decreases the association of the periventricular nucleus with corticosterone, a stress hormone, and increases its association with regions of the parasympathetic nervous system known to have a calming effect. Horm Behav. Young Department of Psychiatry and Beha˝ioral Sciences, Emory Uni˝ersity School of Medicine, 1639 Pierce Dri˝e, Atlanta, GA 30322 USA Accepted 12 August 1997 Abstract Adult prairie .  |  Please enable it to take advantage of the complete set of features! (A) The time course of…, NLM They found that blocking the prairie voles’s oxytocin receptors with the antagonist had no effect in mating-induced aggression and partner preference over other new potential mates (they still exhibited pair-bonding). Clipboard, Search History, and several other advanced features are temporarily unavailable. J Neurosci. There was no main effect of treatment (aCSF versus OTA) on time engaged in any of these behaviors (two-way repeated measures ANOVA; F, Effects of mating and accumbal OTR signaling on Fos-ir across the SSN. As a control region, oxytocin receptor antagonist was also infused into the caudate putamen. Following a test that mimics flooded burrows in the wild and triggers an escape reaction, voles given both oxytocin and a companion snuggle more and struggle less to escape from dry cages than controls do. Get the latest public health information from CDC: Autism spectrum disorder; CRISPR/Cas9; Genome editing; Non-traditional models; Oxytocin receptor; Prairie voles; Social behavior; Social novelty preference. For more reports from the 2010 Society for Neuroscience meeting, please click here. 2019 May;111:60-69. doi: 10.1016/j.yhbeh.2018.10.011. Fig.…, NLM Oxytocin receptor density in the nucleus accumbens is positively correlated with alloparenting in juvenile and adult female prairie voles, and oxytocin receptor antagonist infused into the nucleus accumbens blocks this behavior. This site needs JavaScript to work properly. J Neurosci. Thus, the door-opening behavior in prairie voles can be considered a helping behavior that is motivated by empathy for the distress of conspecifics. Enter multiple addresses on separate lines or separate them with commas. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, Construction of sgRNAs targeting the prairie vole oxytocin receptor gene (, Evidence for functional abnormality of OXTR in. Ogi A, Mariti C, Baragli P, Sergi V, Gazzano A. This is because oxytocin enhances the recognition of socially relevant information, “really making you see the individualness of the individual” — and that this can have a lasting effect, says Young, professor of psychiatry at Emory University. Site-specific administration of OTA into…, Site-specific administration of OTA into the NAc has no effect on male sociosexual…, Effects of mating and accumbal OTR signaling on Fos-ir across the SSN. Natural variation in oxytocin receptor (OXTR) density in the nucleus accumbens (NAcc) is associated with variation in alloparental behavior, and artificially enhancing OXTR expression in the NAcc enhances alloparental behavior and pair bonding in socially monogamous prairie voles.


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