; Pearson, R.M. ; Falgout, B. Escape mutant assays identified five amino acid residues that are critical for neutralization escape. So this "reverse" genetics proceeds from genotype -> phenotype. ; Stockwell, T.B. Chimerivax-west nile virus live-attenuated vaccine: Preclinical evaluation of safety, immunogenicity, and efficacy. Donaldson, E.F.; Yount, B.; Sims, A.C.; Burkett, S.; Pickles, R.J.; Baric, R.S. Rescue of influenza a virus from recombinant DNA. Molecular cloning of the genome of a cardiotropic coxsackie b3 virus: Full-length reverse-transcribed recombinant cdna generates infectious virus in mammalian cells. Webster, L.T. MLM and Emory University are entitled to licensing fees derived from various agreements Emory has entered into non-exclusive licensing agreements related to some of the technologies described in this paper. Moreover, in the absence of a licensed vaccine or antiviral for MERS, this panel of nAbs offers the possibility of developing human mAb-based immunotherapy, especially for health-care workers. ; Osterhaus, A.D.; Fouchier, R.A. The antibodies bound to overlapping epitopes that overlap the receptor binding site on the RBD as suggested by competition experiments and further supported by site-directed mutagenesis of the RBD and a docking model of the m336-RBD complex. Quan, F.S. In addition, little is known about the role of human neutralizing Ab (nAb) pressure as a driving force in MERS-CoV adaptive evolution. [ "article:topic", "authorname:kimballj", "reverse genetics", "Zebrafish", "showtoc:no", "license:ccby" ], 11.11: Antisense Oligodeoxynucleotides and their Therapeutic Potential, It is a vertebrate, like us, and thus can provide clues to human biology that invertebrates like. ; Bates, J.T. Galarza, J.M. ; Stockwell, T.B. Find support for a specific problem on the support section of our website. ; Murphy, B.R. Cohen, J.I. Torovirus (ToV) has recently been classified in the new family Tobaniviridae, although it belonged to the Coronavirus (CoV) family historically. A key hallmark of orthoymyxovirus evolution is the reassortment of the virus genomes through co-infection of a cell. Infectious transcripts of tick-borne encephalitis virus, generated in days by rt-pcr. Evaluation of influenza virus-like particles and novasome adjuvant as candidate vaccine for avian influenza. Its embryos are transparent so defects in development can be seen easily. Reed, W. Recent researches concerning the etiology, propagation, and prevention of yellow fever, by the united states army commission. ; Sastry, M.; Stewart-Jones, G.B. ; Randolph, V.B. Flavivirus diseases range from asymptomatic to severe neurological disease such as encephalitis, meningitis, and myelitis [, Similar to picornaviruses, nearly all flavivirus reverse genetics platforms involve either, Some of the first vaccine efforts were directed at generating inactivated or live-attenuated strains for vaccinations against flaviviruses. Hotez, P.J. Construction of an infectious cdna clone of echovirus 6. Understanding of population structure serves as a foundation for designing new vaccines and drugs as well as to explain emergence of drug resistance amongst subpopulations. Graham, B.S. John F. Enders and measles virus vaccine—A reminiscence. ; Sidhu, M.S. Yun, S.I. Zaki, A.M.; van Boheemen, S.; Bestebroer, T.M. Both authors read and approved the manuscript. Zimmermann, H.; Eggers, H.J. Inoue, T.; Yamaguchi, S.; Saeki, T.; Sekiguchi, K. Production of infectious swine vesicular disease virus from cloned cdna in mammalian cells. Trivalent combined measles-mumps-rubella vaccine. Blount, R.E., Jr.; Morris, J.A. ; Wengler, G.; Perelygin, A.A.; Brinton, M.A. Have questions or comments? To our knowledge, these results provide the first report on human nAbs against MERS-CoV that may contribute to MERS-CoV clearance and evolution. ; Smith, I.; Todd, S.; Arkinstall, R.; Frazer, L.; Monaghan, P.; Smith, G.A. Sumiyoshi, H.; Hoke, C.H. ; Ratterree, M.S. Legal. ; Taber, L.H. and s.c. immunization pathways. ; Lee, S.; Yan, D.; Teng, M.N. Theiler, M.; Smith, H.H. Next generation vaccination strategies include tetravalent or quadrivalent vaccines, which may be grown in animal cell cultures (rather than chicken eggs) or virus-like particles (VLPs) in cultures of, A major frontier of synthetic biology is the development of new vaccines and therapeutics and the improvement of the implementation and efficacy of those already on the market.


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