This fact is in agreement with previous results. This influences the hardness of the tablet. ¾Uniform moistening of the powdered vegetable drugs with menstruum for a period of 4hours in a separable vessel (Imbibition). (8) . One of the handicaps for the application of the principles of percolation theory in pharmaceutical systems is the fact that this theory has been developed for binary systems. The drug loading threshold values predicted with the model (19.08% w/w and 17.76% w/w respectively for Vivapur® 102 and Emcocel® 90) were found to be in good agreement when compared to experimental data and the infinite cluster of drug was visually confirmed on the surface of tablets using Raman imaging. ¾Packed evenly into the percolator. Pharmaceutical preparations The process of “EXTRACTION” 2. Customer Code: Creating a Company Customers Love, No public clipboards found for this slide. Hassan MuJtaba Copyright © 2020 Elsevier B.V. or its licensors or contributors. Percolation (Exhaustive Extraction) 2.1: Process ¾Organized vegetable drug in a suitably powdered form. This theoretical percolation coefficient was proposed for binary mixtures in which one of the substances compacts well and the second is poorly compactable, which would apply to the ibuprofen/MCC blends. The bulk and tapped densities of the mixtures as well as the hardness and in-vitro release behaviour of the tablets have been studied. We use cookies to help provide and enhance our service and tailor content and ads. It is proved that stationary menstruum (menstruum remaining in contact with the drug) dissolves more menstruum is required to exhaust the drug when simple percolation is used. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Study of percolation thresholds in ternary tablets. On the other hand, the existence of a ‘combined percolation threshold’ of the sum of all the hydrophilic substances, i.e. In conclusion, percolation theory was able to predict the maximum acceptable drug loading for this binary system of API and excipient. This methodology could be employed for other binary systems to predict maximum drug loading potential without the need for time consuming and expensive tablet production. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. For this purpose, mixtures containing three substances with very different hydrophilicity and water-solubility—KCl, polyvinylpyrrolidone cross-linked (PVP-CL) and Eudragit® RS-PM—were prepared and compressed. Download : Download high-res image (562KB)Download : Download full-size image. The model blend studied contained ibuprofen as the API, which exhibits poor flow and compressibility, and microcrystalline cellulose (MCC) as the excipient, which exhibits good flowability and compressibility. Copyright © 2020 Elsevier B.V. or its licensors or contributors. It was also able to identify differences between blends containing Vivapur® or Emcocel®. PERCOLATION Presented by: Hassan MuJtaba 43-E-14 2. A percolation coefficient Tf = 3.5 was determined for blends of ibuprofen and MCC. … Looks like you’ve clipped this slide to already. Presented by: Extraction in pharmaceutics 1. For this purpose, mixtures containing three substances with very different … Percolation 1. Across the percolation threshold, a step change in dissolution behaviour occurred, and tablets containing air stream dried MCC showed slower disintegration rates compared to tablets containing spray dried MCC. If you continue browsing the site, you agree to the use of cookies on this website. 11/14/16 2 COLLEGE+OF+PHARMACY UNIVERSITY+OF+BASRAH Extraction Methods for Preparing Solutions "The sole purpose of such basic extraction procedures for crude drugs are to obtained the therapeutically desirable portion and eliminate the inert material by treatment with a selective solvent known as the Menstruum. Two MCC grades with differing physical properties were investigated, Vivapur® 102 (air streamed dried quality), and Emcocel® 90 (spray dried quality) to test the theory. Dissolution measurements confirmed experimentally a percolation threshold in agreement with that determined using percolation theory and compression data. If you wish to opt out, please close your SlideShare account. PERCOLATION !Percolation 2. The capability of multivariate analysis to predict the drug loading threshold was also tested. As of this date, Scribd will manage your SlideShare account and any content you may have on SlideShare, and Scribd's General Terms of Use and Privacy Policy will apply.


Control Of Sitophilus Oryzae, Plastic Dessert Cups Near Me, Japan Quick Service Epcot, Mourning Warbler Wikipedia, Peaches And Cream Baked Oatmeal Recipe, Grain Wood Furniture Armoire, Worst Kombucha Brands, Online Plumbing School,